2. 诱导疾病模型产品 Immunology/Inflammation Epigenetics Metabolic Enzyme/Protease Anti-infection Apoptosis
  3. 免疫与炎症疾病模型 消化系统疾病模型 COX Histone Acetyltransferase Endogenous Metabolite Bacterial Parasite Ferroptosis
  4. 半抗原 肝脏疾病模型
  5. Acetaminophen

Acetaminophen  (Synonyms: 对乙酰氨基酚; Paracetamol; 4-Acetamidophenol; 4'-Hydroxyacetanilide)

目录号: HY-66005 纯度: 99.98%
COA 产品使用指南

摩尔计算器

Acetaminophen (Paracetamol) 是选择性环氧合酶-2 (COX-2) 的抑制剂，IC50 值为 25.8 μM。Acetaminophen 是一种有效的肝 N-乙酰转移酶 2 (NAT2) 抑制剂。Acetaminophen 是广泛使用的解热和止痛剂。Acetaminophen 可以在小鼠体内诱导铁死亡 (ferroptosis)，并造成急性肝损伤。

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Acetaminophen Chemical Structure

Acetaminophen Chemical Structure

CAS No. : 103-90-2

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规格 价格 是否有货 数量
500 mg ￥300
In-stock
5 g ￥400
In-stock
10 g ￥600
In-stock
50 g   询价  

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Customer Review

Other Forms of Acetaminophen:

Acetaminophen 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 44 篇科研文献

WB

    Acetaminophen purchased from MCE. Usage Cited in: Appl Microbiol Biotechnol. 2018 Feb;102(3):1443-1453.  [Abstract]

    Dihydroquercetin relieves APAP-induced necrosis and suppressed ERK/JNK stress responses. Western Blot analysis for phosphor-JNK1/2, β-Actin as a lading control.

    Acetaminophen purchased from MCE. Usage Cited in: Molecules. 2018 Dec 29;24(1). pii: E110.  [Abstract]

    Western analysis of p-Akt protein expression with or without the treatment of APAP.

    Acetaminophen purchased from MCE. Usage Cited in: Molecules. 2018 Dec 29;24(1). pii: E110.  [Abstract]

    Western analysis of Nrf2 protein expression in L-02 cells with or without the treatment of APAP and SHK.

    Acetaminophen purchased from MCE. Usage Cited in: Molecules. 2018 Dec 29;24(1). pii: E110.  [Abstract]

    Western analysis of p-Akt protein expression in L-02 cells with or without the treatment of APAP and SHK.

    Acetaminophen purchased from MCE. Usage Cited in: Theranostics. 2017 Sep 26;7(17):4135-4148.  [Abstract]

    LiposIA inhibits ROS generation and prevents APAP-induced mitochondrial dysfunction in the liver. Immunoblot images of iNOS and p-JNK.

    查看 COX 亚型特异性产品:

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    COX COX-1 COX-2 COX-3

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Acetaminophen (Paracetamol) is a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM; is a widely used antipyretic and analgesic agent.[1][2][3]. Acetaminophen is a potent hepatic N-acetyltransferase 2 (NAT2) inhibitor[4]. Acetaminophen induces ferroptosis and leads to acute liver injury in mice model[5].

    IC50 & Target[1]

    COX-2

    25.8 μM (IC50)

    COX-1

    113.7 μM (IC50)

    体外研究
    (In Vitro)

    In vitro, acetaminophen elicites a 4.4-fold selectivity toward COX-2 inhibition (IC50 113.7 μM for COX-1; IC50 25.8 μM for COX-2). Following oral administration of the drug, maximal ex vivo inhibitions are 56% (COX-1) and 83% (COX-2). Acetaminophen plasma concentrations remaine above the in vitro IC50 for COX-2 for at least 5 h postadministration. Ex vivo IC50 values (COX-1: 105.2 μM; COX-2: 26.3 μM) of acetaminophen compared favorably with its in vitro IC50 values. In contrast to previous concepts, acetaminophen inhibited COX-2 by more than 80%, i.e., to a degree comparable to nonsteroidal antiinflammatory drugs (NSAIDs) and selective COX-2 inhibitors. However, a >95% COX-1 blockade relevant for suppression of platelet function is not achieved[1]. MTT assay shows that Acetaminophen (APAP) in a dose of 50 mM significantly (p<0.001) reduces cell viability to 61.5±6.65%. Interestingly, the significant (p<0.01) increase in cell viability to 79.7±2.47% is observed in the Acetaminophen/HV110 co-treated cells, compared to Acetaminophen treated cells[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Acetaminophen 相关抗体:
    体内研究
    (In Vivo)

    Administering Acetaminophen (250 mg/kg, orally) to the mice causes significant (p<0.001) liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes alanine aminotransferase (ALT), aminotransferase (AST), alkaline phosphatase (ALP), and gamma-glutamyl transferase (γGT) compared with normal group. Conversely, effects of pretreatment with different doses of citral (125, 250, and 500 mg/kg) exhibited a significant (p<0.05) decrease in serum activities of ALT (91.79%, 93.07%, and 95.61%, resp.), AST (93.40%, 91.89%, and 96.52%, resp.), ALP (39.29%, 37.07%, and 59.80%, resp.), and γGT (92.83%, 91.59%, and 93.0%, resp.), when compared to the Acetaminophen group. Similar results were found in pretreatment with SLM on the activity of ALT (95.90%), AST (95.03%), ALP (70.52%), and γGT (92.69%)[3].
    Acetaminophen (300 mg/kg, i.p., single dose) induces ferroptosis, by enhancing levels of Fe2+ and malondialdehyde (MDA), and decreasing levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4), and induces acut eliver injury in C57BL/6J mice model[5].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Acetaminophen induced liver injury in C57BL/6J mice[5]
    Dosage: 300 mg/kg
    Administration: i.p., single dose
    Result: Increased levels of MDA and Fe2+, decreased levels of GSH and GPX4.
    Destoryed the boundary plate, disordered the arrangement of hepatic cords, caused liver cells edema, tissue necrosis and inflammatory cells infiltration
    Clinical Trial
    分子量

    151.16

    Formula

    C8H9NO2
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    对乙酰氨基酚；乙酰氨基酚；扑热息痛；退热净；醋氨酚；对醋氨酚；索密痛；乙酰氨基苯酚；二醋洛尔
    结构分类
    初始来源
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Store at room temperature 3 years

    *该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    溶解性数据
    细胞实验： 

    DMSO 中的溶解度 : 250 mg/mL (1653.88 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

    H2O 中的溶解度 : 10 mg/mL (66.16 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 6.6155 mL 33.0775 mL 66.1551 mL
    5 mM 1.3231 mL 6.6155 mL 13.2310 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物实验：

    以下溶解方案，请直接配制工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

    • 方案 一

      请依序添加每种溶剂： PBS

      Solubility: 6.67 mg/mL (44.13 mM); 澄清溶液; 超声助溶

    • 方案 二

      请依序添加每种溶剂： 50% PEG300    50% Saline

      Solubility: 66.67 mg/mL (441.06 mM); 澄清溶液; Need ultrasonic and heat to 30°C

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    纯度 & 产品资料

    纯度: 99.98%

    COA (283 KB) LCMS (264 KB)

    产品使用指南 (1538 KB)
    参考文献

    Acetaminophen 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度，选择合适的溶剂配制储备液；该产品在溶液状态不稳定，建议您现用现配，即刻使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O / DMSO 1 mM 6.6155 mL 33.0775 mL 66.1551 mL 165.3877 mL
    5 mM 1.3231 mL 6.6155 mL 13.2310 mL 33.0775 mL
    10 mM 0.6616 mL 3.3078 mL 6.6155 mL 16.5388 mL
    15 mM 0.4410 mL 2.2052 mL 4.4103 mL 11.0258 mL
    20 mM 0.3308 mL 1.6539 mL 3.3078 mL 8.2694 mL
    25 mM 0.2646 mL 1.3231 mL 2.6462 mL 6.6155 mL
    30 mM 0.2205 mL 1.1026 mL 2.2052 mL 5.5129 mL
    40 mM 0.1654 mL 0.8269 mL 1.6539 mL 4.1347 mL
    50 mM 0.1323 mL 0.6616 mL 1.3231 mL 3.3078 mL
    60 mM 0.1103 mL 0.5513 mL 1.1026 mL 2.7565 mL
    DMSO 80 mM 0.0827 mL 0.4135 mL 0.8269 mL 2.0673 mL
    100 mM 0.0662 mL 0.3308 mL 0.6616 mL 1.6539 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Acetaminophen103-90-2Paracetamol 4-Acetamidophenol 4'-Hydroxyacetanilide对乙酰氨基酚乙酰氨基酚扑热息痛退热净醋氨酚对醋氨酚索密痛乙酰氨基苯酚二醋洛尔COXHistone AcetyltransferaseEndogenous MetaboliteBacterialParasiteFerroptosisCyclooxygenaseHATsHATInhibitorinhibitorinhibit

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